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The SEQDESIGN Procedure
Overview
Boundaries for Group Sequential Designs
Group Sequential Methods
Getting Started
Syntax
PROC SEQDESIGN Statement
DESIGN Statement
SAMPLESIZE Statement
Details
Fixed-Sample Clinical Trials
One-Sided Fixed-Sample Tests in Clinical Trials
Two-Sided Fixed-Sample Tests in Clinical Trials
Group Sequential Methods
Statistical Assumptions for Group Sequential Designs
Boundary Scales
Boundary Variables
Type I and Type II Errors
Unified Family Methods
Haybittle-Peto Method
Whitehead Methods
Error Spending Methods
Acceptance (beta) Boundary
Boundary Adjustments for Overlapping Lower and Upper beta Boundaries
Specified and Derived Parameters
Applicable Boundary Keys
Sample Size Computation
Applicable One-Sample Tests and Sample Size Computation
Applicable Two-Sample Tests and Sample Size Computation
Applicable Regression Parameter Tests and Sample Size Computation
Aspects of Group Sequential Designs
Summary of Methods in Group Sequential Designs
Table Output
ODS Table Names
Graphics Output
ODS Graphics
Acknowledgments
Examples
Creating Fixed-Sample Designs
Creating a One-Sided O’Brien-Fleming Design
Creating Two-Sided Pocock and O’Brien-Fleming Designs
Generating Graphics Display for Sequential Designs
Creating Designs Using Haybittle-Peto Methods
Creating Designs with Various Stopping Criteria
Creating Whitehead’s Triangular Designs
Creating a One-Sided Error Spending Design
Creating Designs with Various Number of Stages
Creating Two-Sided Error Spending Designs with and without Overlapping Lower and Upper beta Boundaries
Creating a Two-Sided Asymmetric Error Spending Design with Early Stopping to Reject H0
Creating a Two-Sided Asymmetric Error Spending Design with Early Stopping to Reject or Accept H0
References
Details: SEQDESIGN Procedure
Fixed-Sample Clinical Trials
One-Sided Fixed-Sample Tests in Clinical Trials
Two-Sided Fixed-Sample Tests in Clinical Trials
Group Sequential Methods
Statistical Assumptions for Group Sequential Designs
Boundary Scales
Boundary Variables
Type I and Type II Errors
Unified Family Methods
Haybittle-Peto Method
Whitehead Methods
Error Spending Methods
Acceptance (beta) Boundary
Boundary Adjustments for Overlapping Lower and Upper beta Boundaries
Specified and Derived Parameters
Applicable Boundary Keys
Sample Size Computation
Applicable One-Sample Tests and Sample Size Computation
Applicable Two-Sample Tests and Sample Size Computation
Applicable Regression Parameter Tests and Sample Size Computation
Aspects of Group Sequential Designs
Summary of Methods in Group Sequential Designs
Table Output
ODS Table Names
Graphics Output
ODS Graphics
Acknowledgments
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