The MCMC Procedure

The Behrens-Fisher Problem

One of the famous examples in the history of statistics is the Behrens-Fisher problem (Fisher, 1935). Consider the situation where there are two independent samples from two different normal distributions:

\begin{eqnarray*} y_{11}, y_{12}, \cdots , y_{1 n_1} \sim \mbox{normal}(\mu _1, \sigma _1^2) \\ y_{21}, y_{22}, \cdots , y_{2 n_2} \sim \mbox{normal}(\mu _2, \sigma _2^2) \end{eqnarray*}

Note that $n_1 \neq n_2$. When you do not want to assume that the variances are equal, testing the hypothesis $H_0 : \mu _1 = \mu 2$ is a difficult problem in the classical statistics framework, because the distribution under $H_0$ is not known. Within the Bayesian framework, this problem is straightforward because you can estimate the posterior distribution of $\mu _1 - \mu _2$ while taking into account the uncertainties in all of parameters by treating them as random variables.

Suppose you have the following set of data: 

title 'The Behrens-Fisher Problem';

data behrens;
   input y ind @@;
   datalines;
121 1  94 1 119 1 122 1 142 1 168 1 116 1
172 1 155 1 107 1 180 1 119 1 157 1 101 1
145 1 148 1 120 1 147 1 125 1 126 2 125 2
130 2 130 2 122 2 118 2 118 2 111 2 123 2
126 2 127 2 111 2 112 2 121 2
;

The response variable is y, and the ind variable is the group indicator, which takes two values: 1 and 2. There are 19 observations that belong to group 1 and 14 that belong to group 2.

The likelihood functions for the two samples are as follows:

\begin{eqnarray*} p(y_{1i}|\mu _1, \sigma _1^2) & = & \phi (y_{1i}; \mu _1, \sigma _1^2) ~ ~ ~ \mbox{for}~ ~ ~ i = 1, \cdots , 19 \\ p(y_{2j}|\mu _2, \sigma _2^2) & = & \phi (y_{2j}; \mu _2, \sigma _2^2) ~ ~ ~ \mbox{for}~ ~ ~ j = 1, \cdots , 14 \end{eqnarray*}

Berger (1985) showed that a uniform prior on the support of the location parameter is a noninformative prior. The distribution is invariant under location transformations—that is, $\theta = \mu + c$. You can use this prior for the mean parameters in the model:

\begin{eqnarray*} \pi (\mu _1) & \propto & 1 \\ \pi (\mu _2) & \propto & 1 \end{eqnarray*}

In addition, Berger (1985) showed that a prior of the form $1/\sigma ^2$ is noninformative for the scale parameter, and it is invariant under scale transformations (that is $\tau = c \sigma ^2$). You can use this prior for the variance parameters in the model:

\begin{eqnarray*} \pi (\sigma _1^2) & \propto & 1/\sigma _1^2 \\ \pi (\sigma _2^2) & \propto & 1/\sigma _2^2 \end{eqnarray*}

The log densities of the prior distributions on $\sigma _1^2$ and $\sigma _2^2$ are:

\begin{eqnarray*} \log (\pi (\sigma _1^2)) & =& -\log (\sigma _1^2) \\ \log (\pi (\sigma _2^2)) & =& -\log (\sigma _2^2) \end{eqnarray*}

The following statements generate posterior samples of $\mu _1, \mu _2, \sigma _1^2, \sigma _2^2$, and the difference in the means: $\mu _1 - \mu _2$: 

proc mcmc data=behrens outpost=postout seed=123
          nmc=40000 monitor=(_parms_ mudif)
          statistics(alpha=0.01);
   ods select PostSumInt;
   parm mu1 0 mu2 0;
   parm sig21 1;
   parm sig22 1;
   prior mu: ~ general(0);
   prior sig21 ~ general(-log(sig21), lower=0);
   prior sig22 ~ general(-log(sig22), lower=0);
   mudif = mu1 - mu2;
   if ind = 1 then do;
      mu = mu1;
      s2 = sig21;
   end;
   else do;
      mu = mu2;
      s2 = sig22;
   end;
   model y ~ normal(mu, var=s2);
run;

The PROC MCMC statement specifies an input data set (Behrens), an output data set containing the posterior samples (Postout), a random number seed, and the simulation size. The MONITOR= option specifies a list of symbols, which can be either parameters or functions of the parameters in the model, for which inference is to be done. The symbol _parms_ is a shorthand for all model parameters—in this case, mu1, mu2, sig21, and sig22. The symbol mudif is defined in the program as the difference between $\mu _1$ and $\mu _2$.

The global suboption ALPHA=0.01 in the STATISTICS= option specifies 99% highest posterior density (HPD) credible intervals for all parameters.

The ODS SELECT statement displays the summary statistics and interval statistics tables while excluding all other output. For a complete list of ODS tables that PROC MCMC can produce, see the sections Displayed Output and ODS Table Names.

The PARMS statements assign the parameters mu1 and mu2 to the same block, and sig21 and sig22 each to their own separate blocks. There are a total of three blocks. The PARMS statements also assign an initial value to each parameter.

The PRIOR statements specify prior distributions for the parameters. Because the priors are all nonstandard (uniform on the real axis for $\mu _1$ and $\mu _2$ and $1/\sigma ^2$ for $\sigma _1^2$ and $\sigma _2^2$), you must use the GENERAL function here. The argument in the GENERAL function is an expression for the log of the distribution, up to an additive constant. This distribution can have any functional form, as long as it is programmable using SAS functions and expressions. The function specifies a distribution on the log scale, not on the original scale. The log of the prior on mu1 and mu2 is 0, and the log of the priors on sig21 and sig22 are –log(sig21) and –log(sig22) respectively. See the section Specifying a New Distribution for more information about how to specify an arbitrary distribution. The LOWER= option indicates that both variance terms must be strictly positive.

The MUDIF assignment statement calculates the difference between mu1 and mu2. The IF-ELSE statements enable different y’s to have different mean and variance, depending on their group indicator ind. The MODEL statement specifies the normal likelihood function for each observation in the model.

Figure 61.6 displays the posterior summary and interval statistics.

Figure 61.6: Posterior Summary and Interval Statistics

The Behrens-Fisher Problem

The MCMC Procedure

Posterior Summaries and Intervals
Parameter N Mean Standard
Deviation 		99% HPD Interval
mu1 40000 134.8 6.0092 119.1 152.3
mu2 40000 121.4 1.9119 116.1 126.6
sig21 40000 685.0 255.3 260.0 1580.5
sig22 40000 51.1811 23.8675 14.2322 136.0
mudif 40000 13.3730 6.3095 -3.3609 30.7938 




            

            


            
The mean difference has a posterior mean value of 13.37, and the lower endpoints of the 99% credible intervals are negative.
               This suggests that the mean difference is positive with a high probability. However, if you want to estimate the probability
               that $\mu _1 - \mu _2 > 0$, you can do so as follows. 
            

            
The following statements produce Figure 61.7: 


proc format;
   value diffmt low-0 = 'mu1 - mu2 <= 0' 0<-high = 'mu1 - mu2 > 0';
run;

proc freq data = postout;
   tables mudif /nocum;
   format mudif diffmt.;
run;



The sample estimate of the posterior probability that $\mu _1 - \mu _2 > 0$ is 0.98. This example illustrates an advantage of Bayesian analysis. You are not limited to making inferences based on model
               parameters only. You can accurately quantify uncertainties with respect to any function of the parameters, and this allows
               for flexibility and easy interpretations in answering many scientific questions. 
            

            
  

            


Figure 61.7: Estimated Probability of $\mu _1 - \mu _2 > 0$.
               

               

                  

                     
                     

                        
                        
                        

The Behrens-Fisher Problem
                              
                           


The FREQ Procedure

                        
                        

                        
                        

                           
                           

                              
                              








mudif
                                       
                                       Frequency
                                       
                                        Percent
                                       
                                    




mu1 - mu2 <= 0
                                       
                                       753
                                       
                                       1.88
                                       
                                    



mu1 - mu2 > 0
                                       
                                       39247
                                       
                                       98.12