The hypotheses for the paired t test are
The test assumes normally distributed data and requires . The test statistics are
where and are the sample mean and standard deviation of the differences and
and
The test is
Exact power computations for t tests are given in O’Brien and Muller (1993, Section 8.2.2):
The lognormal case is handled by reexpressing the analysis equivalently as a normality-based test on the log-transformed data, by using properties of the lognormal distribution as discussed in Johnson, Kotz, and Balakrishnan (1994, Chapter 14). The approaches in the section Paired t Test (TEST=DIFF) then apply.
In contrast to the usual t test on normal data, the hypotheses with lognormal data are defined in terms of geometric means rather than arithmetic means.
The hypotheses for the paired t test with lognormal pairs are
Let , , , , and be the (arithmetic) means, standard deviations, and correlation of the bivariate normal distribution of the log-transformed data . The hypotheses can be rewritten as follows:
where
and , , and are the coefficients of variation and the correlation of the original untransformed pairs . The conversion from to is given by equation (44.36) on page 27 of Kotz, Balakrishnan, and Johnson (2000) and due to Jones and Miller (1966).
The valid range of is restricted to , where
These bounds are computed from equation (44.36) on page 27 of Kotz, Balakrishnan, and Johnson (2000) by observing that is a monotonically increasing function of and plugging in the values and . Note that when the coefficients of variation are equal (), the bounds simplify to
The test assumes lognormally distributed data and requires . The power is
where
and
The hypotheses for the equivalence test are
The analysis is the two one-sided tests (TOST) procedure of Schuirmann (1987). The test assumes normally distributed data and requires . Phillips (1990) derives an expression for the exact power assuming a two-sample balanced design; the results are easily adapted to a paired design:
where
and is Owen’s Q function, defined in the section Common Notation.
The lognormal case is handled by reexpressing the analysis equivalently as a normality-based test on the log-transformed data, by using properties of the lognormal distribution as discussed in Johnson, Kotz, and Balakrishnan (1994, Chapter 14). The approaches in the section Additive Equivalence Test for Mean Difference with Normal Data (TEST=EQUIV_DIFF) then apply.
In contrast to the additive equivalence test on normal data, the hypotheses with lognormal data are defined in terms of geometric means rather than arithmetic means.
The hypotheses for the equivalence test are
The analysis is the two one-sided tests (TOST) procedure of Schuirmann (1987) on the log-transformed data. The test assumes lognormally distributed data and requires . Diletti, Hauschke, and Steinijans (1991) derive an expression for the exact power assuming a crossover design; the results are easily adapted to a paired design:
where is the standard deviation of the differences between the log-transformed pairs (in other words, the standard deviation of , where and are observations from the treatment and reference, respectively), computed as
where , , and are the coefficients of variation and the correlation of the original untransformed pairs , and is Owen’s Q function. The conversion from to is given by equation (44.36) on page 27 of Kotz, Balakrishnan, and Johnson (2000) and due to Jones and Miller (1966), and Owen’s Q function is defined in the section Common Notation.
The valid range of is restricted to , where
These bounds are computed from equation (44.36) on page 27 of Kotz, Balakrishnan, and Johnson (2000) by observing that is a monotonically increasing function of and plugging in the values and . Note that when the coefficients of variation are equal (), the bounds simplify to
This analysis of precision applies to the standard t-based confidence interval:
where and are the sample mean and standard deviation of the differences. The "half-width" is defined as the distance from the point estimate to a finite endpoint,
A "valid" conference interval captures the true mean difference. The exact probability of obtaining at most the target confidence interval half-width h, unconditional or conditional on validity, is given by Beal (1989):
where
and is Owen’s Q function, defined in the section Common Notation.
A "quality" confidence interval is both sufficiently narrow (half-width ) and valid: