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These sample files and code examples are provided by SAS Institute Inc. "as is" without warranty of any kind, either express or implied, including but not limited to the implied warranties of merchantability and fitness for a particular purpose. Recipients acknowledge and agree that SAS Institute shall not be liable for any damages whatsoever arising out of their use of this material. In addition, SAS Institute will provide no support for the materials contained herein.

data labs (keep=patient relday sday alat biltot alkph asat miny);
   length patient $50;
   label alat="ALAT";
   label biltot="Bilirubin Total";
   label alkph="Alk Phos";
   label asat="ASAT";
   label relday="Day";
   label miny="Trial Duration";

   patient="Patient 5152: White Male Age 48; Drug: A";
   do relday = -25 to 175 by 25;
      alat = 0.5 + 4 * sin(3.14 * (relday+25) / 360.0);
      asat = 0.5 + 3 * sin(3.14 * (relday+25) / 400.0);
      alkph = 0.4 + 2 * sin(3.14 * (relday+25) / 540.0);
      biltot = 0.4 + 1 * sin(3.14 * (relday+25) / 320.0);
      miny=-0.5;
      sday=relday;
      if relday < 0 or relday > 150 then do;
         miny = .;
         sday=.;
      end;
      output;
   end;

   patient="Patient 6416: White Male Age 64; Drug: A";
   do relday = -25 to 70 by 15;
      alat = 1.5 + 2 * sin(3.14 * (relday+25) / 540.0);
      asat = 1.0 + 1 * sin(3.14 * (relday+25) / 540.0);
      alkph = 0.5 + 2 * sin(3.14 * (relday+25) / 360.0);
      biltot = 1.5 + 1 * sin(3.14 * (relday+25) / 360.0);
      miny=-0.5;
      sday=relday;
      if relday < 0 or relday > 60 then do;
         miny = .;
         sday=.;
      end;
      output;
   end;

   patient="Patient 6850: White Male Age 51; Drug: A";
   do relday = -25 to 175 by 25;
      alat = 2 + 1 * sin(3.14 * (relday+25) / 90);
      asat = 1.2 + 1 * sin(3.14 * (relday+25) / 100);
      alkph = 0.7 + 0.5 * sin(3.14 * (relday+25) / 120);
      biltot = 0.3 + 0.2 * sin(3.14 * (relday+25) / 110);
      miny=-0.5;
      sday=relday;
      if relday < 0 or relday > 150 then do;
         miny = .;
         sday=.;
      end;
      output;
   end;

   patient="Patient 6969: White Female Age 48; Drug: B";
   do relday = -25 to 175 by 25;
      alat = 0.5 + 1.5 * sin(3.14 * (relday+25) / 540);
      asat = 0.6 + 1.2 * sin(3.14 * (relday+25) / 480);
      alkph = 0.7 + 1 * sin(3.14 * (relday+25) / 600);
      biltot = 0.3 + 1 * sin(3.14 * (relday+25) / 500);
      miny=-0.5;
      sday=relday;
      if relday < 0 or relday > 150 then do;
         miny = .;
         sday=.;
      end;
      output;
   end;
run;

ods listing close;
ods html file='riskpanel.html' path='.' style=statistical ;
ods graphics / reset width=600px height=400px imagename='RiskPanel' imagefmt=gif ;

title "Liver Function Tests by Trial Day: At Risk Patients";
footnote1 ' ';
footnote2 j=l italic height=8pt
    " For ALAT, ASAT and Alkaline Phosphatase, the Clinical Concern Level is 2 ULN;";
footnote3 j=l italic height=8pt
     " For Bilirubin Total, the CCL is 1.5 ULN: "
     "where ULN is the Upper Level of Normal";

proc sgpanel data=labs cycleattrs;
   panelby patient / novarname;
   series x=relday y=alat / markers lineattrs=(thickness=2px pattern=solid);
   series x=relday y=asat / markers lineattrs=(thickness=2px pattern=solid);
   series x=relday y=alkph / markers lineattrs=(thickness=2px pattern=solid);
   series x=relday y=biltot / markers lineattrs=(thickness=2px pattern=solid);
   band x=sday lower=miny upper=4.5 / transparency=0.8 legendlabel='Trial Duration';
   refline 1 1.5 2 / axis=Y lineattrs=(pattern=dash);
   colaxis min=-50 max= 200 offsetmin=.1 display=(nolabel);
   rowaxis label="Upper Limit Normal";
run;

ods html close;
ods listing;

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These sample files and code examples are provided by SAS Institute Inc. "as is" without warranty of any kind, either express or implied, including but not limited to the implied warranties of merchantability and fitness for a particular purpose. Recipients acknowledge and agree that SAS Institute shall not be liable for any damages whatsoever arising out of their use of this material. In addition, SAS Institute will provide no support for the materials contained herein.

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