Documentation Example 15 for PROC MCMC
/****************************************************************/
/* S A S S A M P L E L I B R A R Y */
/* */
/* NAME: MCMCEX15 */
/* TITLE: Documentation Example 15 for PROC MCMC */
/* Time Dependent Cox Model */
/* PRODUCT: STAT */
/* SYSTEM: ALL */
/* KEYS: */
/* PROCS: MCMC */
/* DATA: */
/* */
/* SUPPORT: Fang Chen */
/* REF: PROC MCMC, EXAMPLE 15 */
/* MISC: */
/****************************************************************/
data Myeloma;
input Time Vstatus LogBUN HGB Platelet Age LogWBC Frac
LogPBM Protein SCalc;
label Time='survival time'
VStatus='0=alive 1=dead';
datalines;
1.25 1 2.2175 9.4 1 67 3.6628 1 1.9542 12 10
1.25 1 1.9395 12.0 1 38 3.9868 1 1.9542 20 18
2.00 1 1.5185 9.8 1 81 3.8751 1 2.0000 2 15
2.00 1 1.7482 11.3 0 75 3.8062 1 1.2553 0 12
2.00 1 1.3010 5.1 0 57 3.7243 1 2.0000 3 9
3.00 1 1.5441 6.7 1 46 4.4757 0 1.9345 12 10
5.00 1 2.2355 10.1 1 50 4.9542 1 1.6628 4 9
5.00 1 1.6812 6.5 1 74 3.7324 0 1.7324 5 9
6.00 1 1.3617 9.0 1 77 3.5441 0 1.4624 1 8
6.00 1 2.1139 10.2 0 70 3.5441 1 1.3617 1 8
6.00 1 1.1139 9.7 1 60 3.5185 1 1.3979 0 10
6.00 1 1.4150 10.4 1 67 3.9294 1 1.6902 0 8
7.00 1 1.9777 9.5 1 48 3.3617 1 1.5682 5 10
7.00 1 1.0414 5.1 0 61 3.7324 1 2.0000 1 10
7.00 1 1.1761 11.4 1 53 3.7243 1 1.5185 1 13
9.00 1 1.7243 8.2 1 55 3.7993 1 1.7404 0 12
11.00 1 1.1139 14.0 1 61 3.8808 1 1.2788 0 10
11.00 1 1.2304 12.0 1 43 3.7709 1 1.1761 1 9
11.00 1 1.3010 13.2 1 65 3.7993 1 1.8195 1 10
11.00 1 1.5682 7.5 1 70 3.8865 0 1.6721 0 12
11.00 1 1.0792 9.6 1 51 3.5051 1 1.9031 0 9
13.00 1 0.7782 5.5 0 60 3.5798 1 1.3979 2 10
14.00 1 1.3979 14.6 1 66 3.7243 1 1.2553 2 10
15.00 1 1.6021 10.6 1 70 3.6902 1 1.4314 0 11
16.00 1 1.3424 9.0 1 48 3.9345 1 2.0000 0 10
16.00 1 1.3222 8.8 1 62 3.6990 1 0.6990 17 10
17.00 1 1.2304 10.0 1 53 3.8808 1 1.4472 4 9
17.00 1 1.5911 11.2 1 68 3.4314 0 1.6128 1 10
18.00 1 1.4472 7.5 1 65 3.5682 0 0.9031 7 8
19.00 1 1.0792 14.4 1 51 3.9191 1 2.0000 6 15
19.00 1 1.2553 7.5 0 60 3.7924 1 1.9294 5 9
24.00 1 1.3010 14.6 1 56 4.0899 1 0.4771 0 9
25.00 1 1.0000 12.4 1 67 3.8195 1 1.6435 0 10
26.00 1 1.2304 11.2 1 49 3.6021 1 2.0000 27 11
32.00 1 1.3222 10.6 1 46 3.6990 1 1.6335 1 9
35.00 1 1.1139 7.0 0 48 3.6532 1 1.1761 4 10
37.00 1 1.6021 11.0 1 63 3.9542 0 1.2041 7 9
41.00 1 1.0000 10.2 1 69 3.4771 1 1.4771 6 10
41.00 1 1.1461 5.0 1 70 3.5185 1 1.3424 0 9
51.00 1 1.5682 7.7 0 74 3.4150 1 1.0414 4 13
52.00 1 1.0000 10.1 1 60 3.8573 1 1.6532 4 10
54.00 1 1.2553 9.0 1 49 3.7243 1 1.6990 2 10
58.00 1 1.2041 12.1 1 42 3.6990 1 1.5798 22 10
66.00 1 1.4472 6.6 1 59 3.7853 1 1.8195 0 9
67.00 1 1.3222 12.8 1 52 3.6435 1 1.0414 1 10
88.00 1 1.1761 10.6 1 47 3.5563 0 1.7559 21 9
89.00 1 1.3222 14.0 1 63 3.6532 1 1.6232 1 9
92.00 1 1.4314 11.0 1 58 4.0755 1 1.4150 4 11
4.00 0 1.9542 10.2 1 59 4.0453 0 0.7782 12 10
4.00 0 1.9243 10.0 1 49 3.9590 0 1.6232 0 13
7.00 0 1.1139 12.4 1 48 3.7993 1 1.8573 0 10
7.00 0 1.5315 10.2 1 81 3.5911 0 1.8808 0 11
8.00 0 1.0792 9.9 1 57 3.8325 1 1.6532 0 8
12.00 0 1.1461 11.6 1 46 3.6435 0 1.1461 0 7
11.00 0 1.6128 14.0 1 60 3.7324 1 1.8451 3 9
12.00 0 1.3979 8.8 1 66 3.8388 1 1.3617 0 9
13.00 0 1.6628 4.9 0 71 3.6435 0 1.7924 0 9
16.00 0 1.1461 13.0 1 55 3.8573 0 0.9031 0 9
19.00 0 1.3222 13.0 1 59 3.7709 1 2.0000 1 10
19.00 0 1.3222 10.8 1 69 3.8808 1 1.5185 0 10
28.00 0 1.2304 7.3 1 82 3.7482 1 1.6721 0 9
41.00 0 1.7559 12.8 1 72 3.7243 1 1.4472 1 9
53.00 0 1.1139 12.0 1 66 3.6128 1 2.0000 1 11
57.00 0 1.2553 12.5 1 66 3.9685 0 1.9542 0 11
77.00 0 1.0792 14.0 1 60 3.6812 0 0.9542 0 12
;
title 'Cox Model with Time Dependent Covariates';
proc sort data = Myeloma;
by descending time;
run;
data _null_;
set Myeloma nobs=_n;
call symputx('N', _n);
stop;
run;
ods select none;
proc freq data=myeloma;
tables time / out=freqs;
run;
ods select all;
proc sort data = freqs;
by descending time;
run;
data myelomaM;
set myeloma;
ind = _N_;
run;
data myelomaM;
merge myelomaM freqs(drop=percent); by descending time;
retain stop;
if first.time then do;
stop = _n_ + count - 1;
end;
run;
%macro array(list);
%global mcmcarray;
%let mcmcarray = ;
%do i = 1 %to 32000;
%let v = %scan(&list, &i, %str( ));
%if %nrbquote(&v) ne %then %do;
array _&v[&n];
%let mcmcarray = &mcmcarray array _&v[&n] _&v.1 - _&v.&n%str(;);
do i = 1 to stop;
set myelomaM(keep=&v) point=i;
_&v[i] = &v;
end;
%end;
%else %let i = 32001;
%end;
%mend;
data z;
set myelomaM;
%array(logbun hgb platelet);
drop vstatus logbun hgb platelet count stop;
run;
data myelomaM;
merge myelomaM z; by descending time;
run;
proc mcmc data=myelomaM outpost=outi nmc=50000 ntu=3000 seed=17
missing=ac;
ods select PostSumInt;
array beta[6];
&mcmcarray
parms (beta:) 0;
prior beta: ~ normal(0, prec=1e-6);
b = (beta1 + beta2 * time) * logbun +
(beta3 + beta4 * time) * hgb +
(beta5 + beta6 * time) * platelet;
S = 0;
do i = 1 to stop;
S = S + exp( (beta1 + beta2 * time) * _logbun[i] +
(beta3 + beta4 * time) * _hgb[i] +
(beta5 + beta6 * time) * _platelet[i]);
end;
loglike = vstatus * (b - log(S));
model general(loglike);
run;
proc mcmc data=myelomaM outpost=outa nmc=50000 ntu=3000 seed=17 jointmodel;
ods select none;
array beta[6]; array timeA[&n]; array vstatusA[&n];
array logbunA[&n]; array hgbA[&n]; array plateletA[&n];
array stopA[&n]; array bZ[&n]; array S[&n];
begincnst;
timeA[ind]=time; vstatusA[ind]=vstatus;
logbunA[ind]=logbun; hgbA[ind]=hgb;
plateletA[ind]=platelet; stopA[ind]=stop;
endcnst;
parms (beta:) 0;
prior beta: ~ normal(0, prec=1e-6);
jl = 0;
do i = 1 to &n;
v1 = beta1 + beta2 * timeA[i];
v2 = beta3 + beta4 * timeA[i];
v3 = beta5 + beta6 * timeA[i];
bZ[i] = v1 * logbunA[i] + v2 * hgbA[i] + v3 * plateletA[i];
/* sum over risk set without considering ties in time. */
S[i] = exp(bZ[i]);
if (i > 1) then do;
do j = 1 to (i-1);
b1 = v1 * logbunA[j] + v2 * hgbA[j] + v3 * plateletA[j];
S[i] = S[i] + exp(b1);
end;
end;
end;
/* make correction to the risk set due to ties in time. */
do i = 1 to &n;
if(stopA[i] > i) then do;
v1 = beta1 + beta2 * timeA[i];
v2 = beta3 + beta4 * timeA[i];
v3 = beta5 + beta6 * timeA[i];
do j = (i+1) to stopA[i];
b1 = v1 * logbunA[j] + v2 * hgbA[j] + v3 * plateletA[j];
S[i] = S[i] + exp(b1);
end;
end;
jl = jl + vstatusA[i] * (bZ[i] - log(S[i]));
end;
model general(jl);
run;
proc compare data=outi compare=outa;
ods select comparesummary;
var beta1-beta6;
run;
proc phreg data=Myeloma;
ods select PostSumInt;
model Time*VStatus(0)=LogBUN z2 hgb z3 platelet z4;
z2 = Time*logbun;
z3 = Time*hgb;
z4 = Time*platelet;
bayes seed=1 nmc=10000 outpost=phout;
run;
