Three Replications with Four Factors

Suppose you want to determine if the order in which four drugs are given affects the response of a subject. If you have only three subjects to test, you can use the following statements to design the experiment.

proc plan seed=27371;
   factors Replicate=3 ordered Drug=4;
run;

These statements produce a design with three replicates of the four levels of the factor Drug arranged in random order. The three levels of Replicate are arranged in order, as shown in Figure 67.1.

Figure 67.1 Three Replications and Four Factors
The PLAN Procedure

Factor Select Levels Order
Replicate 3 3 Ordered
Drug 4 4 Random

Replicate Drug
1 3 2 4 1
2 1 2 4 3
3 4 1 2 3

You might also want to apply one of four different treatments to each cell of this plan (for example, applying different amounts of each drug). The following additional statements create the output shown in Figure 67.2:

   factors Replicate=3 ordered Drug=4;
   treatments Treatment=4;
run;

Figure 67.2 Using the TREATMENTS Statement
The PLAN Procedure

Plot Factors
Factor Select Levels Order
Replicate 3 3 Ordered
Drug 4 4 Random

Treatment Factors
Factor Select Levels Order
Treatment 4 4 Random

Replicate Drug Treatment
1 3 1 2 4 2 1 3 4
2 4 3 2 1 4 1 2 3
3 3 2 4 1 1 4 2 3