More on Mixture Designs

Experimental Task

The following experiment examines quality characteristics of drug tablets based on the levels of certain excipients, the mixing time of the compound, and the load in the tablet compression, as shown in Table 11.1.

Table 11.1: Factors and Responses for PV Tablet Formulation Mixture

Variable	Name	Levels	Description
Mixture Factors	ALPHA	0--1	Alpha-lactose monohydrate
	BETA	0--1	Beta-lactose monohydrate
	PRIMO	0--1	Primotab
Process Factors	MIXTIME	2, 10	Mixing time
	COMPLOAD	1, 2	Compression load
Responses	CRUSHSTR		Crushing strength
	DISSRATE		Dissolution rate

A high crushing strength and low dissolution rate are desirable.