Documentation Example 8 for PROC SEQTEST
/****************************************************************/
/* S A S S A M P L E L I B R A R Y */
/* */
/* NAME: SEQTEX8 */
/* TITLE: Documentation Example 8 for PROC SEQTEST */
/* PRODUCT: STAT */
/* SYSTEM: ALL */
/* KEYS: group sequential test */
/* PROCS: SEQDESIGN, SEQTEST, LOGISTIC */
/* DATA: */
/* */
/* SUPPORT: Yang Yuan UPDATE: Aug 21, 2007 */
/* REF: PROC SEQTEST, EXAMPLE 8 */
/* MISC: */
/****************************************************************/
ods graphics on;
proc seqdesign altref=0.5;
TwoSidedErrorSpending: design method=errfuncpow
method(loweralpha)=errfuncpow(rho=1)
method(upperalpha)=errfuncpow(rho=3)
nstages=3
stop=both;
samplesize model=logistic( prop=0.4 xvariance=0.5345);
ods output Boundary=Bnd_Dose;
run;
data dose;
do j=1 to 93;
do Dose=0, 1, 3, 6;
LDose= log(Dose+1);
gg= 0.4 + 0.12*LDose;
Resp= ranbin( 960303, 1, gg);
output;
end;
end;
run;
data dose_1;
set dose;
if (j <= 31);
run;
data dose_2;
set dose;
if (j <= 62);
run;
data dose_3;
set dose;
if (j <= 93);
run;
proc print data=dose_1(obs=10);
var Resp Dose LDose;
title 'First 10 Obs in the Trial Data';
run;
proc logistic data=Dose_1;
model Resp(event='1')= LDose;
ods output ParameterEstimates=Parms_Dose1;
run;
data Parms_Dose1;
set Parms_Dose1;
if Variable='LDose';
_Scale_='MLE';
_Stage_= 1;
keep _Scale_ _Stage_ Variable Estimate StdErr;
run;
proc print data=Parms_Dose1;
title 'Statistics Computed at Stage 1';
run;
proc seqtest Boundary=Bnd_Dose
Parms(testvar=LDose)=Parms_Dose1
infoadj=prop
order=mle
boundaryscale=mle
;
ods output Test=Test_Dose1;
run;
proc logistic data=dose_2;
model Resp(event='1')=LDose;
ods output ParameterEstimates=Parms_Dose2;
run;
data Parms_Dose2;
set Parms_Dose2;
if Variable='LDose';
_Scale_='MLE';
_Stage_= 2;
keep _Scale_ _Stage_ Variable Estimate StdErr;
run;
proc print data=Parms_Dose2;
title 'Statistics Computed at Stage 2';
run;
proc seqtest Boundary=Test_Dose1
Parms(Testvar=LDose)=Parms_Dose2
infoadj=prop
order=mle
boundaryscale=mle
rci
plots=rci
;
ods output Test=Test_Dose2;
run;