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Documentation Example 3 for PROC PHREG

/****************************************************************/
/*          S A S   S A M P L E   L I B R A R Y                 */
/*                                                              */
/*    NAME: PHREX3                                              */
/*   TITLE: Documentation Example 3 for PROC PHREG              */
/* PRODUCT: STAT                                                */
/*  SYSTEM: ALL                                                 */
/*    KEYS: CLASS effects, Interactions, Backward Elimination,  */
/*          Hazard Ratios                                       */
/*   PROCS: PHREG                                               */
/*    DATA: Kalbfleisch and R.L. Prentice (1980), The           */
/*          Statistical Analysis of Failure Time Data, pp 223-4 */
/* SUPPORT: sasycs                                              */
/*     REF: 9.2 SAS/STAT User's Guide, PROC PHREG Chapter       */
/*    MISC:                                                     */
/****************************************************************/

proc format;
   value yesno 0='no' 10='yes';
run;

data VALung;
   drop check m;
   retain Therapy Cell;
   infile cards column=column;
   length Check $ 1;
   label Time='time to death in days'
         Kps='Karnofsky performance scale'
         Duration='months from diagnosis to randomization'
         Age='age in years'
         Prior='prior therapy'
         Cell='cell type'
         Therapy='type of treatment';
   format Prior yesno.;
   M=Column;
   input Check $ @@;
   if M>Column then M=1;
   if Check='s'|Check='t' then do;
      input @M Therapy $ Cell $;
      delete;
   end;
   else do;
      input @M Time Kps Duration Age Prior @@;
      Status=(Time>0);
      Time=abs(Time);
   end;
   datalines;
standard squamous
 72 60  7 69  0   411 70  5 64 10   228 60  3 38  0   126 60  9 63 10
118 70 11 65 10    10 20  5 49  0    82 40 10 69 10   110 80 29 68  0
314 50 18 43  0  -100 70  6 70  0    42 60  4 81  0     8 40 58 63 10
144 30  4 63  0   -25 80  9 52 10    11 70 11 48 10
standard small
 30 60  3 61  0   384 60  9 42  0     4 40  2 35  0    54 80  4 63 10
 13 60  4 56  0  -123 40  3 55  0   -97 60  5 67  0   153 60 14 63 10
 59 30  2 65  0   117 80  3 46  0    16 30  4 53 10   151 50 12 69  0
 22 60  4 68  0    56 80 12 43 10    21 40  2 55 10    18 20 15 42  0
139 80  2 64  0    20 30  5 65  0    31 75  3 65  0    52 70  2 55  0
287 60 25 66 10    18 30  4 60  0    51 60  1 67  0   122 80 28 53  0
 27 60  8 62  0    54 70  1 67  0     7 50  7 72  0    63 50 11 48  0
392 40  4 68  0    10 40 23 67 10
standard adeno
  8 20 19 61 10    92 70 10 60  0    35 40  6 62  0   117 80  2 38  0
132 80  5 50  0    12 50  4 63 10   162 80  5 64  0     3 30  3 43  0
 95 80  4 34  0
standard large
177 50 16 66 10   162 80  5 62  0   216 50 15 52  0   553 70  2 47  0
278 60 12 63  0    12 40 12 68 10   260 80  5 45  0   200 80 12 41 10
156 70  2 66  0  -182 90  2 62  0   143 90  8 60  0   105 80 11 66  0
103 80  5 38  0   250 70  8 53 10   100 60 13 37 10
test squamous
999 90 12 54 10   112 80  6 60  0   -87 80  3 48  0  -231 50  8 52 10
242 50  1 70  0   991 70  7 50 10   111 70  3 62  0     1 20 21 65 10
587 60  3 58  0   389 90  2 62  0    33 30  6 64  0    25 20 36 63  0
357 70 13 58  0   467 90  2 64  0   201 80 28 52 10     1 50  7 35  0
 30 70 11 63  0    44 60 13 70 10   283 90  2 51  0    15 50 13 40 10
test small
 25 30  2 69  0  -103 70 22 36 10    21 20  4 71  0    13 30  2 62  0
 87 60  2 60  0     2 40 36 44 10    20 30  9 54 10     7 20 11 66  0
 24 60  8 49  0    99 70  3 72  0     8 80  2 68  0    99 85  4 62  0
 61 70  2 71  0    25 70  2 70  0    95 70  1 61  0    80 50 17 71  0
 51 30 87 59 10    29 40  8 67  0
test adeno
 24 40  2 60  0    18 40  5 69 10   -83 99  3 57  0    31 80  3 39  0
 51 60  5 62  0    90 60 22 50 10    52 60  3 43  0    73 60  3 70  0
  8 50  5 66  0    36 70  8 61  0    48 10  4 81  0     7 40  4 58  0
140 70  3 63  0   186 90  3 60  0    84 80  4 62 10    19 50 10 42  0
 45 40  3 69  0    80 40  4 63  0
test large
 52 60  4 45  0   164 70 15 68 10    19 30  4 39 10    53 60 12 66  0
 15 30  5 63  0    43 60 11 49 10   340 80 10 64 10   133 75  1 65  0
111 60  5 64  0   231 70 18 67 10   378 80  4 65  0    49 30  3 37  0
;

proc phreg data=VALung;
   class Prior(ref='no') Cell(ref='large') Therapy(ref='standard');
   model Time*Status(0) = Kps Duration Age Cell Prior|Therapy;
run;

proc phreg data=VALung;
   class Prior(ref='no') Cell(ref='large') Therapy(ref='standard');
   model Time*Status(0) = Kps Duration Age Cell Prior|Therapy
         / selection=backward slstay=0.1;
run;

proc phreg data=VALung;
   class Prior(ref='no') Cell(ref='large') Therapy(ref='standard');
   model Time*Status(0) = Kps Cell Prior|Therapy;
   hazardratio 'H1' Kps / units=10 cl=both;
   hazardratio 'H2' Cell / cl=both;
   hazardratio 'H3' Therapy / diff=ref cl=both;
   contrast 'C1' Kps 10 / estimate=exp;
   contrast 'C2' cell 1  0  0, /* adeno vs large    */
                 cell 1 -1  0, /* adeno vs small    */
                 cell 1  0 -1, /* adeno vs squamous */
                 cell 0 -1  0, /* large vs small    */
                 cell 0  0 -1, /* large vs Squamous */
                 cell 0  1 -1  /* small vs squamous */
                  / estimate=exp;
   contrast 'C3' Prior 0 Therapy 1  Prior*Therapy 0,
                 Prior 0 Therapy 1  Prior*Therapy 1  / estimate=exp;
run;