This example revisits the mixed model problem from the section Getting Started: MIXED Procedure, in Chapter 63: The MIXED Procedure, with the data set shown in the following statements:

data heights; input Family Gender$ Height @@; datalines; 1 F 67 1 F 66 1 F 64 1 M 71 1 M 72 2 F 63 2 F 63 2 F 67 2 M 69 2 M 68 2 M 70 3 F 63 3 M 64 4 F 67 4 F 66 4 M 67 4 M 67 4 M 69 ;

The response variable `Height`

measures the heights (in inches) of 18 individuals. The individuals are classified according to `Family`

and `Gender`

. The following statements fit a mixed model with random effects for `Family`

and the `Family`

*`Gender`

interaction with the MIXED procedure:

proc mixed; class Family Gender; model Height = Gender / s; random Family Family*Gender / s; run;

The “Iteration History” and “Fit Statistics” tables for the optimization in PROC MIXED are shown in Output 48.2.1. The MIXED procedure converges after six iterations and achieves a –2 restricted log likelihood of 71.02246.

Output 48.2.1: Iteration History and Fit Statistics: MIXED Procedure

The Mixed Procedure

Iteration History | |||
---|---|---|---|

Iteration | Evaluations | -2 Res Log Like | Criterion |

0 | 1 | 74.11074833 | |

1 | 2 | 71.51614003 | 0.01441208 |

2 | 1 | 71.13845990 | 0.00412226 |

3 | 1 | 71.03613556 | 0.00058188 |

4 | 1 | 71.02281757 | 0.00001689 |

5 | 1 | 71.02245904 | 0.00000002 |

6 | 1 | 71.02245869 | 0.00000000 |

Fit Statistics | |
---|---|

-2 Res Log Likelihood | 71.0 |

AIC (Smaller is Better) | 77.0 |

AICC (Smaller is Better) | 79.0 |

BIC (Smaller is Better) | 75.2 |

Output 48.2.2 displays the covariance parameter estimates and the solutions for the fixed and random effects. Because the fixed-effect
model contains a classification effect (`Gender`

) and an intercept, the matrix is singular. Only two fixed-effect parameters can be estimated in this model. The MIXED procedure, relying on a sweep
operation in the order in which effects enter the model, determines that the last column of the matrix is a linear function of previous columns. Consequently, the coefficient for the second level of the `Gender`

variable is zero.

Output 48.2.2: Parameter Estimates and Solutions: MIXED Procedure

Covariance Parameter Estimates | |
---|---|

Cov Parm | Estimate |

Family | 2.4010 |

Family*Gender | 1.7657 |

Residual | 2.1668 |

Solution for Fixed Effects | ||||||
---|---|---|---|---|---|---|

Effect | Gender | Estimate | Standard Error | DF | t Value | Pr > |t| |

Intercept | 68.2114 | 1.1477 | 3 | 59.43 | <.0001 | |

Gender | F | -3.3621 | 1.1923 | 3 | -2.82 | 0.0667 |

Gender | M | 0 | . | . | . | . |

Solution for Random Effects | |||||||
---|---|---|---|---|---|---|---|

Effect | Gender | Family | Estimate | Std Err Pred | DF | t Value | Pr > |t| |

Family | 1 | 1.2680 | 1.1201 | 10 | 1.13 | 0.2840 | |

Family | 2 | 0.08980 | 1.1121 | 10 | 0.08 | 0.9372 | |

Family | 3 | -1.6660 | 1.1712 | 10 | -1.42 | 0.1853 | |

Family | 4 | 0.3082 | 1.1201 | 10 | 0.28 | 0.7888 | |

Family*Gender | F | 1 | -0.3198 | 1.0810 | 10 | -0.30 | 0.7734 |

Family*Gender | M | 1 | 1.2523 | 1.0933 | 10 | 1.15 | 0.2787 |

Family*Gender | F | 2 | -0.4299 | 1.0774 | 10 | -0.40 | 0.6983 |

Family*Gender | M | 2 | 0.4959 | 1.0774 | 10 | 0.46 | 0.6551 |

Family*Gender | F | 3 | -0.08229 | 1.1409 | 10 | -0.07 | 0.9439 |

Family*Gender | M | 3 | -1.1429 | 1.1409 | 10 | -1.00 | 0.3401 |

Family*Gender | F | 4 | 0.8320 | 1.0933 | 10 | 0.76 | 0.4642 |

Family*Gender | M | 4 | -0.6053 | 1.0810 | 10 | -0.56 | 0.5878 |

The “Type 3 Tests of Fixed Effects” table in Output 48.2.3 is produced by the MIXED procedure by default.

Output 48.2.3: Test of Gender Effect

Type 3 Tests of Fixed Effects | ||||
---|---|---|---|---|

Effect | Num DF | Den DF | F Value | Pr > F |

Gender | 1 | 3 | 7.95 | 0.0667 |

The same linear mixed model is fit with the HPMIXED procedure with the following statements:

proc hpmixed; class Family Gender; model Height = Gender / s; random Family Family*Gender / s; test gender; run;

Output 48.2.4 displays the “Iteration History” and “Fit Statistics” tables. The HPMIXED procedure, with its default quasi-Newton algorithm, achieves the same –2 restricted log likelihood as the MIXED procedure (71.02246; see Output 48.2.1).

Output 48.2.4: Iteration History and Fit Statistics: HPMIXED Procedure

The HPMIXED Procedure

Iteration History | ||||
---|---|---|---|---|

Iteration | Evaluations | Objective Function |
Change | Max Gradient |

0 | 4 | 71.023177956 | . | 0.034074 |

1 | 3 | 71.022519936 | 0.00065802 | 0.007839 |

2 | 3 | 71.022477283 | 0.00004265 | 0.004674 |

3 | 2 | 71.0224587 | 0.00001858 | 0.000168 |

4 | 2 | 71.022458689 | 0.00000001 | 3.28E-6 |

Fit Statistics | |
---|---|

-2 Res Log Likelihood | 71.02246 |

AIC (Smaller is Better) | 77.02246 |

AICC (Smaller is Better) | 79.02246 |

BIC (Smaller is Better) | 75.18134 |

CAIC (Smaller is Better) | 78.18134 |

HQIC (Smaller is Better) | 72.98226 |

Output 48.2.5 displays the results that correspond to those in Output 48.2.2 in the MIXED procedure.

Output 48.2.5: Parameter Estimates and Solutions: HPMIXED Procedure

Covariance Parameter Estimates | |
---|---|

Cov Parm | Estimate |

Family | 2.4010 |

Family*Gender | 1.7657 |

Residual | 2.1668 |

Solution for Fixed Effects | ||||||
---|---|---|---|---|---|---|

Effect | Gender | Estimate | Standard Error | DF | t Value | Pr > |t| |

Intercept | 0 | . | . | . | . | |

Gender | F | 64.8493 | 1.1477 | 16 | 56.50 | <.0001 |

Gender | M | 68.2114 | 1.1477 | 16 | 59.43 | <.0001 |

Solution for Random Effects | |||||||
---|---|---|---|---|---|---|---|

Effect | Gender | Family | Estimate | Std Err Pred | DF | t Value | Pr > |t| |

Family | 1 | 1.2680 | 1.1201 | 16 | 1.13 | 0.2743 | |

Family | 2 | 0.08980 | 1.1121 | 16 | 0.08 | 0.9366 | |

Family | 3 | -1.6660 | 1.1712 | 16 | -1.42 | 0.1741 | |

Family | 4 | 0.3082 | 1.1201 | 16 | 0.28 | 0.7867 | |

Family*Gender | F | 1 | -0.3198 | 1.0810 | 16 | -0.30 | 0.7712 |

Family*Gender | M | 1 | 1.2523 | 1.0933 | 16 | 1.15 | 0.2689 |

Family*Gender | F | 2 | -0.4299 | 1.0774 | 16 | -0.40 | 0.6951 |

Family*Gender | M | 2 | 0.4959 | 1.0774 | 16 | 0.46 | 0.6515 |

Family*Gender | F | 3 | -0.08229 | 1.1409 | 16 | -0.07 | 0.9434 |

Family*Gender | M | 3 | -1.1429 | 1.1409 | 16 | -1.00 | 0.3314 |

Family*Gender | F | 4 | 0.8320 | 1.0933 | 16 | 0.76 | 0.4577 |

Family*Gender | M | 4 | -0.6053 | 1.0810 | 16 | -0.56 | 0.5832 |

A number of points are noteworthy in comparing the results from the procedures. The covariance parameter estimates are the same, yet the solutions for the fixed effects differ. In fact, both solutions are correct. Solving a sparse system of linear equations requires reordering of the mixed model equations to minimize memory consumption in the factorization process. As a consequence, the order in which singularities are detected can differ from the order in which effects enter the model. Mathematically, the two sets of solutions simply correspond to different choices for the generalized inverse in solving a singular linear system. See the sections Generalized Inverse Matrices and Linear Model Theory, in Chapter 3: Introduction to Statistical Modeling with SAS/STAT Software, for more information about the role and importance of generalized inverses in linear model analysis.

Although the two sets of solutions for the fixed effects correspond to different choices of generalized inverses, many important
results are invariant to the choice of the g-inverse. For example, the solutions for the random effects in Output 48.2.5 and Output 48.2.2 are identical. Also, the test for the `Gender`

effect yields the same F value in both analyses (compare Output 48.2.6 and Output 48.2.3). However, note that the p-values associated with both F tests and t tests differ between the two procedures. This is due to their different default methods for computing the degrees of freedom.
For this model, the HPMIXED procedure use the residual method to determine the denominator degrees of freedom for tests of
fixed effects, whereas the MIXED procedure uses the containment method. The containment method is order-dependent, and thus
not available in the HPMIXED procedure.

Output 48.2.6: Parameter Estimates and Solutions: HPMIXED Procedure

Type III Tests of Fixed Effects | ||||
---|---|---|---|---|

Effect | Num DF | Den DF | F Value | Pr > F |

Gender | 1 | 16 | 7.95 | 0.0123 |