The GLIMMIX procedure generalizes the MIXED and GENMOD procedures in two important ways. First, the response can have a nonnormal distribution. The MIXED procedure assumes that the response is normally (Gaussian) distributed. Second, the GLIMMIX procedure incorporates random effects in the model and so allows for subject-specific (conditional) and population-averaged (marginal) inference. The GENMOD procedure allows only for marginal inference.
The GLIMMIX and MIXED procedure are closely related; see the syntax and feature comparison in the section Comparing the GLIMMIX and MIXED Procedures. The remainder of this section compares the GLIMMIX procedure with the GENMOD, NLMIXED, LOGISTIC, and CATMOD procedures.
The GENMOD procedure fits generalized linear models for independent data by maximum likelihood. It can also handle correlated data through the marginal GEE approach of Liang and Zeger (1986) and Zeger and Liang (1986). The GEE implementation in the GENMOD procedure is a marginal method that does not incorporate random effects. The GEE estimation in the GENMOD procedure relies on R-side covariances only, and the unknown parameters in are estimated by the method of moments. The GLIMMIX procedure allows G-side random effects and R-side covariances. PROC GLIMMIX can fit marginal (GEE-type) models, but the covariance parameters are not estimated by the method of moments. The parameters are estimated by likelihood-based techniques. When the GLIMMIX and GENMOD procedures fit a generalized linear model where the distribution contains a scale parameter, such as the normal, gamma, inverse Gaussian, or negative binomial distribution, the scale parameter is reported in the “Parameter Estimates” table. For some distributions, the parameterization of this parameter differs. See the section Scale and Dispersion Parameters for details about how the GLIMMIX procedure parameterizes the log-likelihood functions and information about how the reported quantities differ between the two procedures.
Many of the fit statistics and tests in the GENMOD procedure are based on the likelihood. In a GLMM it is not always possible to derive the log likelihood of the data. Even if the log likelihood is tractable, it might be computationally infeasible. In some cases, the objective function must be constructed based on a substitute model. In other cases, only the first two moments of the marginal distribution can be approximated. Consequently, obtaining likelihood-based tests and statistics is difficult for many generalized linear mixed models. The GLIMMIX procedure relies heavily on linearization and Taylor-series techniques to construct Wald-type test statistics and confidence intervals. Likelihood ratio tests and confidence intervals for covariance parameters are available in the GLIMMIX procedure through the COVTEST statement.
The NLMIXED procedure fits nonlinear mixed models where the conditional mean function is a general nonlinear function. The class of generalized linear mixed models is a special case of the nonlinear mixed models; hence some of the models you can fit with PROC NLMIXED can also be fit with the GLIMMIX procedure. The NLMIXED procedure relies by default on approximating the marginal log likelihood through adaptive Gaussian quadrature. In the GLIMMIX procedure, maximum likelihood estimation by adaptive Gaussian quadrature is available with the METHOD=QUAD option in the PROC GLIMMIX statement. The default estimation methods thus differ between the NLMIXED and GLIMMIX procedures, because adaptive quadrature is possible for only a subset of the models available with the GLIMMIX procedure. If you choose METHOD=LAPLACE or METHOD=QUAD(QPOINTS=1) in the PROC GLIMMIX statement for a generalized linear mixed model, the GLIMMIX procedure performs maximum likelihood estimation based on a Laplace approximation of the marginal log likelihood. This is equivalent to the QPOINTS=1 option in the NLMIXED procedure.
The LOGISTIC and CATMOD procedures also fit generalized linear models; PROC LOGISTIC accommodates the independence case only. Binary, binomial, multinomial models for ordered data, and generalized logit models that can be fit with PROC LOGISTIC can also be fit with the GLIMMIX procedure. The diagnostic tools and capabilities specific to such data implemented in the LOGISTIC procedure go beyond the capabilities of the GLIMMIX procedure.