The Power and Sample Size Application |

The Example |

Suppose you want to compare survival rates for an existing cancer treatment and a new treatment. You intend to use a log-rank test to compare the overall survival curves for the two treatments. You want to determine a sample size to achieve a power of 0.8 for a two-sided test using a balanced design, with a significance level of 0.05.

The survival curve of patients for the existing treatment is known to be approximately exponential with a median survival time of five years. You think that the proposed treatment will yield a survival curve described by the times and probabilities listed in Table 69.9. Patients are to be accrued uniformly over two years and followed for three years.

Time |
Probability |
---|---|

1 |
0.95 |

2 |
0.90 |

3 |
0.75 |

4 |
0.70 |

5 |
0.60 |

To create a new survival analysis project, select **File****New**, Then, under the **Survival Analysis** section, select **Two-sample survival rank tests** and click **OK**. The **Two-sample survival rank tests** project appears with the Edit Properties page displayed.

For the example, change the project description to `Comparing cancer treatments using two-sample survival rank test`.

Click the **Solve For** tab to select the quantity to solve for. For this example, select the **Sample size per group** option, as shown in Figure 69.78. For information about calculating total sample size, see the section Solving for Sample Size.

In this analysis you can solve for power, sample size per group, or total sample size.

Click the **Test** tab to select a rank test. For this example, select the **Log-rank** option, as shown in Figure 69.79.

Several rank tests are available: Gehan, log-rank, and Tarone-Ware. The Gehan test is most sensitive to survival differences near the beginning of the study period, the log-rank test is uniformly sensitive throughout the study period, and the Tarone-Ware test is somewhere in between.

Click the **Hypothesis** tab to select a one- or two-sided test. For the example, select the **Two-sided test** option, as shown in Figure 69.80.

You can choose either a one- or two-sided test. For the one-sided test, the alternative hypothesis is assumed to be in the same direction as the effect. If you do not know the direction of the effect (that is, whether it is positive or negative), the two-sided test is appropriate. If you know the effect’s direction, the one-sided test is appropriate. If you specify a one-sided test and the effect is in the unexpected direction, the results of the analysis are invalid.

Click the **Alpha** tab to enter one or more values for the significance level. For the example, enter the desired significance level of 0.05 in the first cell of the Alpha table, as shown in Figure 69.81, if it is not already the default value.

The significance level is the probability of falsely rejecting the null hypothesis. If you frequently use the same values for alpha, set them as the defaults in the Preferences window.

Click the **Survival Functions** tab to select the input form for the survival functions.

Examine the input alternatives available in the **Select a form** list. There are four alternate forms for entering survival functions. The first three apply only to exponential curves; the fourth applies to both piecewise linear and exponential curves.

**Group median survival times**

Enter median survival times for the two groups.**Group hazards**

Enter hazards for the two groups.**Hazards, Hazard ratios**

Enter hazards for the reference group and hazard ratios.**Survival curves**

Enter survival probabilities and their associated times for each of several curves. Select or enter the number of curves from the drop-down list; at least two curves are required. Then, for each curve, select it in the left-hand list, select the Group 1 or Group 2 option, and then define the survival curve by entering pairs of times and probabilities. Enter a time and probability pair only if the probability is less than that of the previous pair.

For information about using the other forms, see the section Using the Other Survival Curve Forms.

For each survival curve, select the curve in the left-hand list. Then, enter a descriptive label and select which group it is for. The labels should be unique. Finally, enter pairs of survival times and probabilities.

When you enter probabilities, enter a time and probability pair only when the probability for a survival curve changes. For example, if the probability for curve 1 at time 1 and 2 is 0.9 and at time 3 is 0.8, enter 0.9 for time 1 and 0.8 for time 3.

To specify an exponential survival curve, enter a single time and probability pair. In the example, the exponential curve for the existing treatment is defined by a probability of 0.5 at time 5.

The units of time for the survival curves must correspond to the units for the accrual, follow-up, and total times, which are described in the section Accrual Times.

You can also compare several survival curves. For example, if you have two scenarios, A and B, for group 1’s curve and two scenarios, C and D, for group 2’s curve, then specify probabilities for the four curves and assign A and B to group 1 and C and D to group 2.

For the example, select the **Survival curves** form, as shown in Figure 69.82. Enter the value, 2, in the **Number of survival curves** list box.

For the example enter the following values:

For the first survival curve, enter a label of

`Existing treatment`and select the**Group 1**option. For the first curve, enter a time of 5 and a probability of 0.5. Figure 69.83 shows the resulting values.

For the second curve select

`Function 2`in the selection list on the left side of the tab. Enter a label of`Proposed treatment`and select the**Group 2**option. Then, enter time values of 1 through 5 and the corresponding probabilities of 0.95, 0.9, 0.75, 0.7, and 0.6. To add rows to the table, click the button beneath the table.Figure 69.84 shows these values; the last row of the time and probability table is not displayed.

Click the **Accrual times** tab to select an input form for accrual times and to enter the times.

Examine the alternatives available in the **Select a form** list.

Accrual time is the period during which subjects are brought into the study. Follow-up time is the period during which subjects are observed after all subjects have been included in the study. Total time is the sum of accrual and follow-up time. The units of time for the accrual, follow-up, and total times must correspond to the units you used specified for the survival curves.

When you enter survival curves, the sum of the accrual and follow-up times must be less than the largest time for each survival curve. This does not apply to survival curves represented by a single time, which represent exponential curves.

On the **Accrual Times** tab, there are three alternate forms for entering accrual and follow-up times:

**Accrual times, Follow-up times**

Enter accrual and follow-up times.**Accrual times, Total times**

Enter accrual and total times.**Follow-up times, Total times**

Enter follow-up and total times.

For the example, select the **Accrual times, Follow-up times** form. Then enter a single value of `2` in the Accrual table and a value of `3` in the Follow-up table, as shown in Figure 69.85.

Click the **Power** tab to enter one or more power values. For the example, enter a single value of `0.8`.

When you calculate sample size, it is necessary to specify one or more powers.

Table 69.10 contains the values of the input parameters for the example.

Parameter |
Value |
---|---|

Solve for |
Sample size per group |

Test |
Log-rank |

Hypothesis |
Two-sided test |

Alpha |
0.05 |

Survival function form |
Survival curves |

Survival curves |
See Table 69.11 and Table 69.12 |

Accrual and follow-up times form |
Accrual time, Follow-up times |

Accrual times |
2 |

Follow-up times |
3 |

Power |
0.8 |

Table 69.11 and Table 69.12 contain times and probabilities for the two survival curves, respectively.

Time |
Probability |
---|---|

5 |
0.5 |

Time |
Probability |
---|---|

1 |
0.95 |

2 |
0.90 |

3 |
0.75 |

4 |
0.70 |

5 |
0.60 |

Click the **Results** tab to specify the desired result options. For the example, request both results by selecting both the **Create summary table** and **Create power by sample size graph** check boxes.

Specifying only one power (as in this example) produces a graph with a single point. You might be interested in a plot of sample sizes for a range of powers—say, between 0.75 and 0.85. You can customize the graph by specifying the values for the power axis. Also, you might want to change the appearance of the graph to have sample size (per group) on the vertical axis and power on the horizontal axis.

Click the **Customize** button beside the **Create power by sample size graph** check box to customize the graph. The Customize Graph window is displayed, as shown in Figure 69.86.

Click the **Axis Orientation** tab to select which variable to plot on the vertical axis. For the example, select the **Quantity solved for** option, as shown in Figure 69.86. This option plots sample size on the vertical axis and power on the horizontal axis. You could also have chosen the **Sample size** option.

Click the **Value Ranges** tab to enter minimum and maximum values for a plot axis. For the example, enter a minimum of `0.75` and a maximum of `0.85` in the Powers text boxes. This sets the range of values on the axis for powers. The completed Value Ranges tab of the window is displayed in Figure 69.87. You can set the axis values only for the quantity that is not being solved for.

Click **OK** to save the values that you have entered and return to the Edit Properties page.

Then, click **Calculate** to perform the analysis. If there are no errors in the input parameter values, the View Results page appears. If there are errors in the input parameter values, you are prompted to correct them.

The results appear in separate tabs on the View Results page of the project. Select the tab of each result that you want to view.

Click the **Summary Table** tab to view the summary table. It is composed of two subtables. As shown in Figure 69.88, the `Fixed Scenario Elements` and `Computed N Per Group` tables include the values of the input parameters and the computed quantity (in this case, sample size per group, `N per group`). The sample size per group for the single requested scenario is 226.

Click the **Graph** tab to view the power by sample size graph.

As you can see in Figure 69.89, the graph is curved slightly upward with larger powers associated with larger sample sizes. Sample size is plotted on the vertical axis as requested in the Customize Graph window.

Click the **Narratives** tab to create one or more narratives. To generate a narrative, select the single scenario in the narrative selector table at the bottom of the tab. The narrative for this task does not include the survival times and probabilities for the survival curves:

For a log-rank test comparing two survival curves with a two-sided significance level of 0.05, assuming uniform accrual with an accrual time of 2 and a follow-up time of 3, a sample size of 226 per group is required to obtain a power of at least 0.8 for the exponential curve, "Existing treatment," and the piecewise linear curve, "Proposed treatment." The actual power is 0.800.

For information about selecting additional narratives when multiple scenarios are present, see the section Creating Narratives.

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