PROC SGPLOT provides a simple way to make a variety of scatter plots. This example is taken from  Example 59.4 of Chapter 59: The LOESS Procedure. The ENSO data set, which contains information about differences in ocean pressure over time, is available from the Sashelp library. 
            
The following statements create a scatter plot of points along with a penalized B-spline fit to the data and produce Figure 21.61:
proc sgplot data=sashelp.enso noautolegend;
   title 'Atmospheric Pressure Differences between '
         'Easter Island and Darwin, Australia';
   pbspline y=pressure x=year;
run;
See Chapter 104: The TRANSREG Procedure, for more information about penalized B-splines. Also see the section Grouped Scatter Plot with PROC SGPLOT and Figure 21.12 for an example of a scatter plot with groups of observations.