| The PHREG Procedure |
Let
be one of the likelihood functions described in the previous subsections. Let
. Finding
such that
is maximized is equivalent to finding the solution
to the likelihood equations
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With
as the initial solution, the iterative scheme is expressed as
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The term after the minus sign is the Newton-Raphson step. If the likelihood function evaluated at
is less than that evaluated at
, then
is recomputed using half the step size. The iterative scheme continues until convergence is obtained—that is, until
is sufficiently close to
. Then the maximum likelihood estimate of
is
.
The model-based variance estimate of
is obtained by inverting the information matrix
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