The criteria for an orthogonally confounded design reduce to requiring that no generalized interactions in a certain set can be confounded with zero. (See the section Structure of General Factorial Designs for a definition of generalized interaction.) This section presents the general definition of . First, define three sets, as follows:
the set of effects that you want to estimate
the set of effects that you do not want to estimate but that have unknown nonzero magnitudes (referred to as nonnegligible effects)
the set of all generalized interactions between block pseudo-factors
Furthermore, for any two sets of effects and , denote by the set of all generalized interactions between the effects in and the effects in .
Then the general rules for creating the set of effects that are not to be confounded with zero are as follows:
Put in . This ensures that all effects in are estimable.
Put in . This ensures that all pairs of effects in are unconfounded with each other.
Put in . This ensures that effects in are unconfounded with effects in .
Put in . This ensures that all blocks occur in the design.
Put in . This ensures that effects in are unconfounded with blocks.