The ALLELE Procedure

Measures of Marker Informativeness

Polymorphism Information Content

The polymorphism information content (PIC) measures the probability of differentiating the allele transmitted by a given parent to its child given the marker genotype of father, mother, and child (Botstein et al. 1980). It is computed as

\[  \mbox{PIC} = 1- \sum _{u=1}^ k \tilde{p}_ u^2 - \sum _{u=1}^{k-1} \sum _{v=u+1}^ k 2\tilde{p}_ u^2\tilde{p}_ v^2  \]

Heterozygosity

The heterozygosity, sometimes called the observed heterozygosity, is simply the proportion of heterozygous individuals in the data set and is calculated as

\[  \mbox{Het} = 1 - \sum _{u=1}^ k \tilde{P}_{uu}  \]

Allelic Diversity

The allelic diversity, sometimes called the expected heterozygosity, is the expected proportion of heterozygous individuals in the data set when HWE holds. It is calculated as

\[  \mbox{Div} = 1- \sum _{u=1}^ k \tilde{p}_ u^2  \]